422711-M
KN-93，水溶性
This KN-93 is a water-soluble version of KN-93 that acts as a reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM for rat brain).
别名:
KN-93，水溶性
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 5 mg/mL
Quality Level
General description
也可以5 mM H2O溶液（目录号508315）提供。
CaM激酶II抑制剂KN-93（目录号422708）的水溶性形式。抑制葡萄糖诱导的和毛喉素刺激的离体胰岛的胰岛素释放。对蛋白激酶A活性没有明显的影响。诱导NIH 3T3细胞G1细胞周期阻滞和凋亡。
Biochem/physiol Actions
主要靶标
钙调蛋白依赖性蛋白激酶（CaM激酶）2
钙调蛋白依赖性蛋白激酶（CaM激酶）2
靶标Ki：Cam激酶2为370 nM
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Other Notes
Tombes, R.M., et al. 1995.Cell Growth Differ.6, 1063.
Chen, C., et al. 1994.Science266, 291.
Mamiya, N., et al. 1993.Biochem.Biophys.Res. Commun.195, 608.
Nicki, I., et al. 1993.Biochem.Biophys.Res. Commun.191, 255.
Sumi, M., et al. 1991.Biochem.Biophys.Res. Commun.181, 968.
Tokumitsu, H., et al. 1990.J. Biol. Chem.265, 4315.
Chen, C., et al. 1994.Science266, 291.
Mamiya, N., et al. 1993.Biochem.Biophys.Res. Commun.195, 608.
Nicki, I., et al. 1993.Biochem.Biophys.Res. Commun.191, 255.
Sumi, M., et al. 1991.Biochem.Biophys.Res. Commun.181, 968.
Tokumitsu, H., et al. 1990.J. Biol. Chem.265, 4315.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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