产品名称
脂多糖，大肠埃希菌O111：B4, Lipopolysaccharide, E. coli O111: B4 stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes
description
RTECS - OJ0895400
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
≤2.0% Protein
≤2.5% nucleic acid
solubility
soluble (H2O (5 mg/ml) or 0.5% triethylamine (1 mg/ml). To achieve complete solubilization, heating solution to 37°C with intermittent vortexing or sonication may be necessary.)
shipped in
ambient
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
主要靶标
诱导型一氧化氮合酶
诱导型一氧化氮合酶
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Disclaimer
毒性：有害（C）
General description
内毒素脂多糖可启动多种生化细胞激活途径（PKC，cAMP依赖性蛋白激酶，花生四烯酸代谢，蛋白豆蔻酰化和G蛋白激活）。为了阐明和定义内毒素休克的相关病理生理参数，已经对这些独特的大分子进行了广泛的研究，内毒素休克是脓毒症威胁生命的严重后果。最近，这些细菌产物由于其多能免疫刺激活性而引起了强烈的兴趣，表现为宿主细胞（例如B淋巴细胞，巨噬细胞）对功能分化的激活。脂多糖激活的宿主细胞产生一系列激素活性淋巴因子和单核因子，包括干扰素（α，β和γ），白介素（IL-1和IL-6），肿瘤坏死因子，血小板活化因子和促凝组织因子。刺激诱导型一氧化氮合酶的活性。诱导小鼠胸腺和猪淋巴细胞凋亡。
刺激诱导型一氧化氮合酶的活性。诱导小鼠胸腺和猪淋巴细胞凋亡。
Other Notes
Hattori, S., et al. 1995.Biochem.Mol.Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995.Biochem.Pharmacol.49, 115.
Norimatsu, M., et al. 1995.Infect.Immun.63, 1122.
Feinstein, D.L., et al. 1993.J. Neurochem.60, 1945.
Zhang, Y.H., et al. 1993.Infect.Immun.61, 5044.
Jackson, S.K., et al. 1992.Biochim.Biophys.Acta1135, 165.
O′Sullivan, M.G., et al. 1992.J. Biol. Chem.267, 14547.
Watanabe, K., et al. 1992.J. Cell.Physiol.150, 433.
Morrison, D.C., and Ryan, J.L.1987.Annu.Rev. Med.38, 417.
Mayeux, P.R., et al. 1995.Biochem.Pharmacol.49, 115.
Norimatsu, M., et al. 1995.Infect.Immun.63, 1122.
Feinstein, D.L., et al. 1993.J. Neurochem.60, 1945.
Zhang, Y.H., et al. 1993.Infect.Immun.61, 5044.
Jackson, S.K., et al. 1992.Biochim.Biophys.Acta1135, 165.
O′Sullivan, M.G., et al. 1992.J. Biol. Chem.267, 14547.
Watanabe, K., et al. 1992.J. Cell.Physiol.150, 433.
Morrison, D.C., and Ryan, J.L.1987.Annu.Rev. Med.38, 417.
Preparation Note
为了完全溶解，可能需要将溶液加热至37°C，并间歇涡旋或超声处理。
在复溶后存放于冰箱（4°C）。储备液在 4°C 条件下可稳定保存 6 个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Zhan Zhao et al.
Journal of neuroinflammation, 17(1), 64-64 (2020-02-20)
Sepsis-associated acute brain inflammation, if unresolved, may cause chronic neuroinflammation and resultant neurodegenerative diseases. However, little is known how the transition from acute to chronic neuroinflammation, which is critical for the following progressive neurodegeneration, occurs in sepsis. The goal of
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