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437720

Lipoxin A₄

Name: Lipoxin A<SUB>4</SUB>
Brand: MM

Lipoxin A₄, CAS 89663-86-5, is a potent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides.

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别名:

Lipoxin A₄, LXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7- trans-9- trans-11- cis-13- trans-tetraenoic Acid, LXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7-trans-9-trans-11-cis-13-trans-tetraenoic Acid

经验公式（希尔记法）:

C₂₀H₃₂O₅

CAS号:

89663-86-5

分子量:

352.47

MDL编号:

MFCD00065845

质量水平

100

检测方案

≥95% (HPLC)

形式

liquid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze

溶解性

ethanol: soluble

运输

wet ice

储存温度

−70°C

InChI

1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1

InChI key

IXAQOQZEOGMIQS-SSQFXEBMSA-N

一般描述

Caution! Product contains volatile liquid. Keep product cold at all times.

Potent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB₄ in stimulating human neutrophils to generate superoxides. Involved in contractile responses and acts as a potent enhancer of human protein kinase C. Stimulates the rapid lipid remodeling and pertussis-sensitive release of arachidonic acid in polymorphonuclear leukocytes.

Potent inhibitor of cytotoxic activity of human natural killer cells; shown to be as potent as LTB₄ in stimulating human neutrophils to generate superoxides. Involved in contractile responses and acts as a potent activator of human protein kinase C. Stimulates rapid lipid remodeling and pertussis-sensitive release of arachidonic acid in polymorphonuclear leukocytes. Stimulates MAP kinases via activation of G protein-coupled receptors.

生化/生理作用

Cell permeable: no

Primary Target
Potent inhibitor of cytotoxic activity of human natural killer cells

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Flammable (J)

外形

In Ethanol.

重悬

Following initial thaw, aliquot and freeze (-70°C).

其他说明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

McMahon, B., et al. 2000. J. Biol. Chem. 275, 27566.
Soyombo, O., et al. 1994. Allergy 49, 230.
Flore, S., et al. 1992. J. Biol. Chem.267, 16168.
Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA86, 3438.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

GHS02,GHS07

警示用语：

Danger

危险声明

H225 - H319

预防措施声明

P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338

危险分类

Eye Irrit. 2 - Flam. Liq. 2

储存分类代码

3 - Flammable liquids

WGK

WGK 2

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示例

T1503

货号

25G

包装规格/数量

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Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors.

B McMahon et al.

The Journal of biological chemistry, 275(36), 27566-27575 (2000-06-28)

The lipoxygenase-derived eicosanoids leukotrienes and lipoxins are well defined regulators of hemeodynamics and leukocyte recruitment in inflammatory conditions. Here, we describe a novel bioaction of lipoxin A(4) (LXA(4)), namely inhibition of leukotriene D(4) (LTD(4))-induced human renal mesangial cell proliferation, and

Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: evidence for competition at a common receptor.

K F Badr et al.

Proceedings of the National Academy of Sciences of the United States of America, 86(9), 3438-3442 (1989-05-01)

Lipoxin A4 (LXA4) was competitive with [3H]leukotriene D4 (LTD4) for specific binding to cultured rat glomerular mesangial cells. Half-maximal inhibition was obtained with 100 nM LXA4, compared with 10 nM for unlabeled LTD4. At 10 and 50 nM LXA4 induced

Effects of lipoxin A4 on chemotaxis and degranulation of human eosinophils stimulated by platelet-activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylalanine.

O Soyombo et al.

Allergy, 49(4), 230-234 (1994-04-01)

Lipoxins are trihydroxytetraene metabolites derived through a double lipoxygenation of arachidonic acid. Lipoxin A4 (LXA4) was prepared by total chemical synthesis, and its capacity to modulate eosinophil migration has been evaluated. LXA4 is a weak and partial chemotactic agent; at

Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils.

S Fiore et al.

The Journal of biological chemistry, 267(23), 16168-16176 (1992-08-15)

Lipoxin A4 stimulates rapid lipid remodeling and a pertussis toxin-sensitive release of arachidonic acid in polymorphonuclear leukocytes (PMN) (Nigam, S., Fiore, S., Luscinskas, F.W., and Serhan, C.N. (1990) J. Cell. Physiol. 143, 512-523) and has been shown to inhibit leukocyte

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