438192
抗LRP，轻链小鼠单克隆抗体（5A6）
liquid, clone 5A6, Calbiochem®
别名:
抗低密度脂蛋白受体相关性蛋白
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
5A6, monoclonal
Species reactivity:
rabbit, mouse, human
Application:
Citations:
7
产品名称
抗LRP，轻链小鼠单克隆抗体（5A6）, liquid, clone 5A6, Calbiochem®
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
5A6, monoclonal
form
liquid
does not contain
preservative
species reactivity
rabbit, mouse, human
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
dilution
(Frozen Sections (1-5 µg/mL)
Immunoblotting (1-5 µg/mL)
Paraffin Sections (1-5 µg/mL, )
isotype
IgG2
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LRP1(4035)
Application
冷冻切片（1-5 g/mLµ）
免疫印迹（1-5 µg/mL）
石蜡切片（1-5 µg/mL，请参阅应用参考文献）
免疫印迹（1-5 µg/mL）
石蜡切片（1-5 µg/mL，请参阅应用参考文献）
Disclaimer
毒性：标准处理（A）
General description
纯化的小鼠单克隆抗体。在非还原条件下可识别~85 kDa LRP轻链蛋白。
识别 〜85 kDa LRP 蛋白。
该抗LRP轻链小鼠mAb（5A6）经验证可用于冰冻切片、免疫印迹和石蜡切片，以检测LRP轻链。
Immunogen
人
纯化人胎盘LRP
Other Notes
Mikhailenko, I., et al. 2001.J. Biol. Chem.276, 39484.
Rebeck, W.G., et al. 2001.Mol.Brain Res.87, 238.
Coukos, G., et al. 1994.Am. J. Pathol.144, 383.
Daugherty, A., and Rateri, D.L.1994.Arterioscler Thromb.14, 2017.
Strickland, D.K., et al. 1990.J. Biol. Chem.265, 17401.
Rebeck, W.G., et al. 2001.Mol.Brain Res.87, 238.
Coukos, G., et al. 1994.Am. J. Pathol.144, 383.
Daugherty, A., and Rateri, D.L.1994.Arterioscler Thromb.14, 2017.
Strickland, D.K., et al. 1990.J. Biol. Chem.265, 17401.
合适的工作稀释度由与测定条件相关的变量决定。
Packaging
请参考小瓶标签的批号特定浓度。
Physical form
在100 mM NaCl，50 mM磷酸钠，1 mM EDTA，pH值6.6中。
Preparation Note
初次融化后，等分并冷冻（-20°C）。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Junling Yang et al.
Journal of molecular neuroscience : MN, 49(2), 277-288 (2012-09-05)
We previously reported that anti-amyloid-beta (Aβ) single-chain antibody (scFv59) brain delivery via recombinant adeno-associated virus (rAAV) was effective in reducing cerebral Aβ load in an Alzheimer's disease (AD) mouse model without inducing inflammation. Here, we investigated the prophylactic effects and
Robert D Bell et al.
Nature cell biology, 11(2), 143-153 (2008-12-23)
Amyloid beta-peptide (Abeta) deposition in cerebral vessels contributes to cerebral amyloid angiopathy (CAA) in Alzheimer's disease (AD). Here, we report that in AD patients and two mouse models of AD, overexpression of serum response factor (SRF) and myocardin (MYOCD) in
Abhay P Sagare et al.
The Journal of biological chemistry, 288(21), 15154-15166 (2013-04-13)
Soluble low density lipoprotein receptor-related protein-1 (sLRP1) binds ~70% of amyloid β-peptide (Aβ) in human plasma. In Alzheimer disease (AD) and individuals with mild cognitive impairment converting to AD, plasma sLRP1 levels are reduced and sLRP1 is oxidized, which results
Arne Herring et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(1), 117-128 (2011-09-29)
Physical activity protects brain function in healthy individuals and those with Alzheimer's disease (AD). Evidence for beneficial effects of parental exercise on the health status of their progeny is sparse and limited to nondiseased individuals. Here, we questioned whether maternal
Tomomi Kiyota et al.
Journal of neuroimmunology, 319, 80-92 (2018-03-27)
We investigated the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on behavioral and pathological outcomes in Alzheimer's disease (AD) and non-transgenic mice. GM-CSF treatment in AD mice reduced brain amyloidosis, increased plasma Aβ, and rescued cognitive impairment with increased hippocampal
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