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442630-M

GMBS

Name: GMBS
Brand: MM

别名:

GMBS, N-γ-Maleimidobutyryloxysuccinimide

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₂N₂O₆

化学文摘社编号:

80307-12-6

分子量:

280.23

UNSPSC Code:

12161500

NACRES:

NA.24

MDL number:

MFCD00036817

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属性

assay

≥90% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

storage temp.

−20°C

SMILES string

N2(C(=O)CCC2=O)OC(=O)CCCN1C(=O)C=CC1=O

InChI

1S/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2

InChI key

PVGATNRYUYNBHO-UHFFFAOYSA-N

说明

General description

Heterobifunctional reagent useful for preparation of conjugates such as secondary antibodies and β-galactosidase for EIA procedures or for immobilizing enzymes on solid supports.

N-γ-maleimidobutyryloxysuccinimide ester (GMBS) is an aliphatic crosslinker for immunotoxins (IT).(1) It is used for the generation of conjugated Poly-γ-D-glutamic acid.

Application

GMBS is suitable for use:

as a hetero-bifunctional cross-linking reagent for the immobilization of neural adhesion molecule L1 onto silicon dioxide surface
for the crosslinking of biochips with functionalized gold nanoparticles
for coating salinized capillary tube prior to neutravidin treatment in biosensor sandwich immunoassay

Preparation Note

Reconstitute to 10 mg/ml in tetrahydrofuran or DMSO. Add 1 ml of this stock solution dropwise, with stirring, to 10 ml of 20 mM phosphate buffer.

Other Notes

Rusin, K.M., et al. 1992. Biosens. Bioelectron. 7, 367.
Kitagawa, T., et al. 1983. J. Biochem. 94, 1160.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Biomolecules detection using a silver-enhanced gold nanoparticle-based biochip

Nanoscale Research Letters, 5, 533-533 (2010)

Detection of water-borne E. coli O157 using the integrating waveguide biosensor

Biosensors And Bioelectronics, 21, 678-683 (2005)

Poly-gamma-D-glutamic acid and protective antigen conjugate vaccines induce functional antibodies against the protective antigen and capsule of Bacillus anthracis in guinea-pigs and rabbits

FEMS Immunology and Medical Microbiology, 57, Lee DY-Lee DY (2009)

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全球贸易项目编号

货号	GTIN
442630-100MG	04055977205312