442630-M
GMBS
别名:
GMBS, N-γ-Maleimidobutyryloxysuccinimide
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关于此项目
经验公式（希尔记法）:
C12H12N2O6
化学文摘社编号:
分子量:
280.23
UNSPSC Code:
12161500
NACRES:
NA.24
MDL number:
SMILES string
N2(C(=O)CCC2=O)OC(=O)CCCN1C(=O)C=CC1=O
InChI
1S/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2
InChI key
PVGATNRYUYNBHO-UHFFFAOYSA-N
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
storage temp.
−20°C
Quality Level
General description
Heterobifunctional reagent useful for preparation of conjugates such as secondary antibodies and β-galactosidase for EIA procedures or for immobilizing enzymes on solid supports.
N-γ-maleimidobutyryloxysuccinimide ester (GMBS) is an aliphatic crosslinker for immunotoxins (IT).(1) It is used for the generation of conjugated Poly-γ-D-glutamic acid.
Application
GMBS is suitable for use:
- as a hetero-bifunctional cross-linking reagent for the immobilization of neural adhesion molecule L1 onto silicon dioxide surface
- for the crosslinking of biochips with functionalized gold nanoparticles
- for coating salinized capillary tube prior to neutravidin treatment in biosensor sandwich immunoassay
Preparation Note
Reconstitute to 10 mg/ml in tetrahydrofuran or DMSO. Add 1 ml of this stock solution dropwise, with stirring, to 10 ml of 20 mM phosphate buffer.
Other Notes
Rusin, K.M., et al. 1992. Biosens. Bioelectron. 7, 367.
Kitagawa, T., et al. 1983. J. Biochem. 94, 1160.
Kitagawa, T., et al. 1983. J. Biochem. 94, 1160.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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