444249
基质金属蛋白酶MMP-2/MMP-9抑制剂II
The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
基质金属蛋白酶MMP-2/MMP-9抑制剂II, （2R）-[（4-联苯磺酰基）氨基]-N-羟基-3-苯基丙酰胺，BiPS，BiPS
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关于此项目
经验公式（希尔记法）:
C21H20N2O4S
化学文摘社编号:
分子量:
396.46
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
产品名称
基质金属蛋白酶MMP-2/MMP-9抑制剂II, The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 100 mg/mL
methanol: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
Biochem/physiol Actions
主要靶标
MMP-2
MMP-2
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：MMP-2和MMP-9分别为17 nM和30 nM
Disclaimer
毒性：标准处理（A）
General description
IV型胶原酶的有效抑制剂，MMP-2（IC50=17 nM）和MMP-9（IC50=30 nM）。还显示出可以有效诱导并快速激活HIF。已显示在鼠模型中体内抑制Lewis肺癌诱导的肺定植。
MMP-2（IC50=17 nM）和MMP-9（IC50=30 nM）的有效抑制剂。还显示出可以有效诱导并快速激活HIF。据报告在鼠模型中抑制Lewis肺癌诱导的肺定植。
Other Notes
Lauzier, M.C., et al. 2008.Mol.Pharmacol.In press.
Mifune, M., et al. 2005.J. Biol. Chem.280, 26592.
Zhang, H., et al. 2004.Circ.Res.95, 989.
Tamura, Y., et al. 1998.J. Med. Chem.41, 640.
Mifune, M., et al. 2005.J. Biol. Chem.280, 26592.
Zhang, H., et al. 2004.Circ.Res.95, 989.
Tamura, Y., et al. 1998.J. Med. Chem.41, 640.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多6个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
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