444250
MMP Inhibitor I
The MMP Inhibitor I controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
MMP Inhibitor I, FN-439
产品名称
MMP Inhibitor I, The MMP Inhibitor I controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
form
solid
assay
≥95% (HPLC)
potency
1 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
MMP-1, MMP-8
MMP-1, MMP-8
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
A tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC50 = 1 µM), granulocyte gelatinase (MMP-9; IC50 = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. No. 53702) or human neutrophil elastase.
Other Notes
4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]
Hagemamn, T., et al. 2004. Carcinogenesis25, 1543.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Jörg Weiske et al.
Methods in molecular biology (Clifton, N.J.), 289, 175-192 (2004-10-27)
In epidermal cells desmosomes represent major sites of basolateral cell-cell contacts that play an important role for epidermal homeostasis. Excess or damaged cells are often removed by apoptosis. To release apoptotic cells from the tissue, intercellular contacts have to be
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