A cell-permeable and highly, piperazine-based potent inhibitor of MMP-9 (IC₅₀ = 900 pM) and MMP-13 (IC₅₀ = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC₅₀ = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC₅₀ = 930 nM).

A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC₅₀ = 900 pM) and MMP-13 (IC₅₀ = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC₅₀ = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC₅₀ = 930 nM).

Cell permeable: yes

Primary Target
MMP-9

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 900 pM against both MMP-9 and MMP-13

Packaged under inert gas

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Cheng, M., et al. 2000. J. Med. Chem.43, 369.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany