444278-M
MMP-9抑制剂I
≥93% (HPLC), solid, MMP-9 inhibitor, Calbiochem®
别名:
MMP-9抑制剂I
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关于此项目
经验公式（希尔记法）:
C27H33N3O5S
化学文摘社编号:
分子量:
511.63
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥93% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
产品名称
MMP-9抑制剂I, MMP-9 Inhibitor I, CAS 1177749-58-4, is a cell-permeable, potent, and reversible MMP-9 Inhibitor (IC50 = 5 nM). At high concentration inhibits MMP-1 (IC50 = 1.05 µM) & MMP-13 (IC50 = 113 nM).
Quality Segment
assay
≥93% (HPLC)
form
solid
potency
5 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 10 mg/mL
storage temp.
−20°C
SMILES string
[S](=O)(N(Cc3ccccc3)c2c(cc(cc2C(=O)NO)CN(CC)CC)C)Oc1ccc(cc1)OC
InChI
1S/C27H33N3O5S/c1-5-29(6-2)18-22-16-20(3)26(25(17-22)27(31)28-32)30(19-21-10-8-7-9-11-21)36(33)35-24-14-12-23(34-4)13-15-24/h7-17,32H,5-6,18-19H2,1-4H3,(H,28,31)
InChI key
OIYCVCCJVZCTIX-UHFFFAOYSA-N
General description
细胞可渗透，强效，选择性和可逆的MMP-9抑制剂（IC50 nM）。仅在高得多的浓度下抑制MMP-1（IC50 = 1.05 µM）和MMP-13（IC50 =113 nM）。
Biochem/physiol Actions
主要靶标
MMP-9
MMP-9
Preparation Note
复溶后等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多6个月。
Other Notes
Levin, J.I., et al. 2001.Bioorg.Med. Chem. Lett.11, 2189.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable