444285
MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem
The MMP-2/MMP-9 Inhibitor V, also referenced under CAS 869577-53-7, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem, (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS
登录并加购，请在购物车里查看协议价、货期和发货地。
选择规格
变更视图
关于此项目
Quality Segment
assay
≥85% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (Ki = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (Ki = 3.6 µM, 295 µM, and >25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and >25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target Ki: 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively
Packaging
Packaged under inert gas
Other Notes
Ikejiri, M., et al. 2005. J. Biol. Chem.280, 33992.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13