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About This Item
经验公式（希尔记法）:
C17H20N2O5S
CAS Number:
分子量:
364.42
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
methanol: 100 mg/mL
DMSO: 200 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[S](=O)(=O)(N(OC(C)C)CC(=O)NO)c1ccc(cc1)c2ccccc2
InChI
1S/C17H20N2O5S/c1-13(2)24-19(12-17(20)18-21)25(22,23)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13,21H,12H2,1-2H3,(H,18,20)
InChI key
PHGLPDURIUEELR-UHFFFAOYSA-N
一般描述
A cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn2+-binding site-targeting inhibitor of MMP-2 (IC50 = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC50 = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC50 >50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.
生化/生理作用
Cell permeable: yes
Primary Target
MMP-2
MMP-2
Product does not compete with ATP.
Reversible: no
Target IC50: 12 nM against MMP-2
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Tuccinardi, T., et al. 2006. Bioorg. Med. Chem.14, 4260.
Rossello, A., et al. 2004. Bioorg. Med. Chem.12, 2441.
Rossello, A., et al. 2004. Bioorg. Med. Chem.12, 2441.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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