444291
MMP408
≥94% (HPLC), solid, MMP-12 inhibitor, Calbiochem®
别名:
MMP-12抑制剂，MMP408, （S）-2-（8-（甲氧基羰基氨基）二苯并[b，d]呋喃-3-磺酰胺基）-3-甲基丁酸
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关于此项目
经验公式（希尔记法）:
C19H20N2O7S
化学文摘社编号:
分子量:
420.44
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
MMP-12抑制剂，MMP408, The MMP-12 Inhibitor, MMP408, also referenced under CAS 1258003-93-8, controls the biological activity of MMP-12. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
assay
≥94% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Disclaimer
毒性：标准处理（A）
General description
一种二苯并呋喃基磺酰胺基缬氨酸化合物，可作为有效的活性位点锌靶向MMP-12选择性抑制剂（对人MMP-12的IC50 =2 nM），对小鼠/大鼠/绵羊物种的MMP-12（分别为IC50=160、320和22.3 nM）或人MMP-3/13/14（分别为IC50=351、120和1100 nM）的活性弱得多，并且对人Agg-1/2（IC50 >5 µM），TACE（IC50 >25 µM）和MMP-1/7（IC50 >6 µM）几乎无效。MMP408在小鼠中具有口服活性，并显示可有效减轻rhMMP-12诱导的小鼠体内肺组织炎症反应超过50%（5 mg/kg，p.o.，b.i.d.）。
Other Notes
Li, W., et al. 2009.J. Med. Chem.52, 1799.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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