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Merck
CN

454565

Methyl Arachidonyl Fluorophosphonate - Calbiochem

别名:

Methyl Arachidonyl Fluorophosphonate - Calbiochem, MAFP, cPLA2α Inhibitor III

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关于此项目

经验公式（希尔记法）:
C21H36FO2P
分子量:
370.48
UNSPSC Code:
12352200

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assay

≥98% (TLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

General description

This product has been discontinued.



A selective, active site-directed, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic (85 kDa) phospholipase A2 (PLA2) but not of secretory PLA2.

A selective, active site-directed, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic (85 kDa) phospholipase A2 (PLA2) but not secretory PLA2.

Biochem/physiol Actions

Primary Target
calcium-dependent and calcium-independent cytosolic (85 kDa) phospholipase A2 (PLA2)
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Physical form

In methyl acetate.

Preparation Note

Prior to use, evaporate the methyl acetate and resuspend in high quality chloroform. Aliquot and immediately evaporate the chloroform. Store aliquots at -70°C. Reconstitute in DMSO just prior to use.

Other Notes

Balsinde, J., and Dennis, E.A. 1996. J. Biol. Chem. 271, 6758.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta1302, 55.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

法规信息

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J Balsinde et al.
The Journal of biological chemistry, 271(12), 6758-6765 (1996-03-22)
Receptor-stimulated arachidonic acid (AA) mobilization in P388D1 macrophages consists of a transient phase in which AA accumulates in the cell and a sustained phase in which AA accumulates in the incubation medium. We have shown previously that a secretory group
Y C Lio et al.
Biochimica et biophysica acta, 1302(1), 55-60 (1996-07-12)
Methyl arachidonyl fluorophosphonate (MAFP) has been recently reported to be a selective, active-site directed, irreversible inhibitor of the Group IV 85 kDa cytosolic phospholipase A2 (cPLA2). We have now shown that this compound also potently inhibits the Ca(2+)-independent cytosolic phospholipase

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