474780
MG-115
Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).
别名:
MG-115
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关于此项目
经验公式（希尔记法）:
C25H39N3O5
化学文摘社编号:
分子量:
461.59
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥90% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N([C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC)C=O)C(=O)OCc1ccccc1
InChI
1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
InChI key
QEJRGURBLQWEOU-FKBYEOEOSA-N
General description
有效的可逆蛋白酶体抑制剂（20S和26S蛋白酶体的Ki 分别为21 nM和35 nM）。特异性抑制蛋白酶体的胰凝乳蛋白酶样活性，并诱导大鼠-1和PC12细胞中的凋亡。
Biochem/physiol Actions
主要靶标
20S蛋白酶体
20S蛋白酶体
产物不与ATP竞争。
可逆性：是
细胞渗透性：否
靶标Ki：20S和26S蛋白酶体分别为21 nM和35 nM
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Other Notes
Lopes, U.G., et al. 1997.J. Biol. Chem. 272, 12893.
Lee, D.H., and Goldberg, A.L.1996.J. Biol. Chem.271, 27280.
Palombella, V.J., et al. 1994.Cell 78, 773.Rock, K.L., et al. 1994.Cell 78, 761.
Vinitsky, A., et al. 1992.Biochemistry 31, 9421.
Lee, D.H., and Goldberg, A.L.1996.J. Biol. Chem.271, 27280.
Palombella, V.J., et al. 1994.Cell 78, 773.Rock, K.L., et al. 1994.Cell 78, 761.
Vinitsky, A., et al. 1992.Biochemistry 31, 9421.
Z-Leu-Leu-Nva-CHO
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable