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Merck
CN

474787

MG-132

≥95% (HPLC), proteasome inhibitor, powder

别名:

Z-Leu-Leu-Leu-al, MG-132

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关于此项目

经验公式（希尔记法）:
C26H41N3O5
化学文摘社编号:
133407-82-6
分子量:
475.62
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00674886

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产品名称

MG-132，HPLC检测显示纯度≥95%, Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).

SMILES string

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-VABKMULXSA-N

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 25 mg/mL
ethanol: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

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Disclaimer

毒性：标准处理（A）

General description

高效、可逆和细胞可透过性蛋白酶体抑制剂(Ki = 4 nM)。通过26S复合物减少哺乳动物细胞和酵母的可渗透染色中泛素结合蛋白的降解，而不会影响其ATPase或异肽酶的活性。可激活c-Jun N端激酶（JNK1），从而启动细胞凋亡。抑制NF-κB的活化（IC50 = 3 µM）。该材料经HPLC测试为≥95%纯。 另提供经HPLC测试为≥98%纯度产品（货号474790）。也可以提供20 mM的DMSO溶液（目录号474788）。

Other Notes

Steinhilb, M.L., et al. 2001.J. Biol. Chem.276, 4476.
Meriin, A.B., et al. 1998.J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996.Ann.Rep.Med. Chem.31, 279.
Klafki, H.W., et al. 1996.J. Biol. Chem.271, 2865.
Lee, D.H., and Goldberg, A.L., 1996.J. Biol. Chem.271, 27280.
Wiertz, E.J., et al. 1996.Cell84, 769.
Jensen, T.J., et al. 1995.Cell 83, 129.
Read, M.A., et al. 1995.Immunity2, 493.
Rock, K.L., et al. 1994.Cell 78, 761.

Packaging

用惰性气体包装

Preparation Note

溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

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