474788
MG-132
≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem®
别名:
InSolution MG-132 in EtOH, ≥95% by HPLC, Proteasome Inhibitor XI
产品名称
MG-132 in EtOH, ≥95% by HPLC, InSolution, ≥95%, reversible proteasome inhibitor
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
protect from light
shipped in
ambient
storage temp.
−70°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Ki = 4 nM for proteasomal inhibition
Reversible: yes
Secondary Target
IKK
IKK
Disclaimer
Toxicity: Flammable (J)
General description
Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κBactivation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Packaging
Packaged under inert gas
Preparation Note
Following initital thaw, aliquot and freeze (-70°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
53.6 °F - closed cup - Information refers to the main ingredient.
flash_point_c
12 °C - closed cup - Information refers to the main ingredient.
法规信息
危险化学品
此项目有
Mitchell H Omar et al.
The Biochemical journal, 480(12), 875-890 (2023-06-12)
Cushing's syndrome is an endocrine disorder caused by excess production of the stress hormone cortisol. Precision medicine strategies have identified single allele mutations within the PRKACA gene that drive adrenal Cushing's syndrome. These mutations promote perturbations in the catalytic core
Chitra Rawat et al.
Cancer research, 83(24), 4142-4160 (2023-10-06)
Prostate cancer remains the second leading cause of cancer death in men in Western cultures. A deeper understanding of the mechanisms by which prostate cancer cells divide to support tumor growth could help devise strategies to overcome treatment resistance and
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