475837
ISO-1
≥98% (HPLC), solid, MIF antagonist, Calbiochem®
别名:
MIF拮抗剂，ISO-1
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关于此项目
经验公式（希尔记法）:
C12H13NO4
化学文摘社编号:
分子量:
235.24
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
MIF拮抗剂，ISO-1, The MIF Antagonist, ISO-1, also referenced under CAS 478336-92-4, controls the biological activity of MIF.
InChI
1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3
InChI key
AIXMJTYHQHQJLU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
light yellow
solubility
DMSO: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
主要靶标
MIF互变异构
MIF互变异构
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：D-多巴色素互变异构酶为7 µM
Disclaimer
毒性：标准处理（A）
General description
具有抗炎特性的可渗透细胞的异恶唑啉化合物。通过结合MIF互变异构酶的催化活性位（D-多巴色素互变异构酶的IC50 = 7 µM）来抑制MIF互变异构酶的活性，并抑制人单核细胞中TNFα，PGE2和COX-2的产生以及RAW 264.7巨噬细胞中花生四烯酸的产生。在免疫炎症性糖尿病的小鼠模型中显示出抗糖尿病特性。也可以50 mM的DMSO溶液（货号505225）提供。
Other Notes
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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