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Merck
CN

475838

米非司酮

≥99% (titration), solid, progesterone and glucocorticoid receptor antagonist, Calbiochem®

别名:

米非司酮

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关于此项目

经验公式（希尔记法）:
C29H35NO2
化学文摘社编号:
84371-65-3
分子量:
429.59
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00867226

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产品名称

米非司酮, A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors.

SMILES string

N(C)(C)c1ccc(cc1)[C@H]2C[C@]3([C@H]([C@@H]4CCC5=CC(=O)CCC5=C42)CC[C@@]3(O)C#CC)C

InChI

1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1

InChI key

VKHAHZOOUSRJNA-GCNJZUOMSA-N

description

Merck USA index - 14, 6186

assay

≥99% (titration)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

impurities

≤0.1% Steroid substances

color

yellow

solubility

ethanol: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

主要靶标
孕激素和糖皮质激素受体
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有

Disclaimer

毒性：致癌/致畸（D）

General description

一种可渗透细胞的合成类固醇，作为孕激素和糖皮质激素受体的有效拮抗剂。抑制P-糖蛋白（P-gp）功能并下调P-gp介导的抗药性。显示抗血管生成作用并抑制血管内皮生长因子（VEGF）的产生。调节小鼠子宫内膜中Fas和FasL的表达以及前列腺癌细胞中TRAIL的表达。作为一种抗氧化剂，可提供针对CA1锥体细胞中受控皮层撞击（CCI）的神经保护作用，以及对小鼠海马HT22细胞的Aβ-，H2O2-和谷氨酸诱导性的损伤的神经保护作用。
一种可透过细胞的合成类固醇，作为孕激素和糖皮质激素受体的有效拮抗剂。 据报告可抑制P-糖蛋白（P-gp）功能并下调P-gp介导的抗药性。还显示抗血管生成作用并抑制血管内皮生长因子（VEGF）的产生。显示调节小鼠子宫内膜中Fas和FasL的表达以及前列腺癌细胞中TRAIL的表达。作为一种抗氧化剂，据报告可提供针对CA1锥体细胞中受控皮层撞击（CCI）的神经保护作用，以及对小鼠海马HT22细胞的Aβ-，H2O2-和谷氨酸诱导性的损伤的神经保护作用。

Other Notes

McCullers, D.L., et al. 2002.Neuroscience109, 219.
Sidell, N., et al. 2002.Ann.N. Y. Acad.Sci.955, 159.
Gao, F., et al. 2001.Acta Pharmacol.Sin.22, 524.
Hyder, S.M., et al. 2001.Int. J. Cancer92, 469.
Lam, F.C., et al. 2001.J. Neurochem.76, 1121.
Sridhar, S., et al. 2001.Cancer Res.61, 7179.
Behl, C., et al. 1997.Eur. J. Neurosci.9, 912.
Greb, R.R., et al. 1997.Hum.Reprod.12, 1280.
Gruol, D.J., et al. 1994.Cancer Res.54, 3088.

Packaging

用惰性气体包装

Preparation Note

复溶后等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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