475846
MIF Antagonist III, 4-IPP
别名:
MIF Antagonist III, 4-IPP, Macrophage Migration Inhibitory Factor Antagonist III, 4-IPP, 4-Iodo-6-phenylpyrimidine
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关于此项目
经验公式（希尔记法）:
C10H7IN2
化学文摘社编号:
分子量:
282.08
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
Ic1ncnc(c1)c2ccccc2
InChI
1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
InChI key
ZTCJXHNJVLUUMR-UHFFFAOYSA-N
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
amber
solubility
DMSO: 50 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat. No. 475837) in cell-free dopachrome tautomerase activity assays (IC50 ~5 vs. 50 µM, respectively, using recombinant human MIF) as well as in cell-based migration assays (50% vs 0% inhibition with respective inhibitor at 10 µM) and anchorage-independent growth (57% vs 0% inhibition with respective inhibitor at 10 µM) using human lung adenocarcinoma A549. Also shown to reduce A549 cellular active Rac1 population (50 µM, 16 h) in vitro and effectively decrease liver tautomerase activity by 50% in mice (1 mg/animal/day or ~50 mg/kg/day via i.p.) in vivo.
Packaging
Packaged under inert gas
Other Notes
Winner, M., et al. 2008. Cancer Res.68, 7253.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
Ricardo A de Azevedo et al.
Oncoimmunology, 9(1), 1846915-1846915 (2020-12-22)
Immune checkpoint blockade (ICB) has demonstrated an impressive outcome in patients with metastatic melanoma, yet, durable complete response; even with Ipilimumab/Nivolumab combo are under 30%. Primary and acquired resistance in response to ICB is commonly due to a tumor immune
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