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经验公式(希尔记法):
C21H16N4O · xH2O
化学文摘社编号:
分子量:
340.38 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
InChI key
NIKCVKMHGQQSRN-UHFFFAOYSA-N
SMILES string
[nH]1c2c(cc1c3cc(ncc3)c4cnc5c(c4)cccc5)C(=O)NCC2.O
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale yellow
solubility
DMSO: 50 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC50 = 8.5, 81, and 210 nM agaisnt MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Anderson, D.R., et al. 2007. J. Med. Chem.50, 2647.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Gregory Fettweis et al.
Biochimica et biophysica acta. Molecular cell research, 1864(1), 113-124 (2016-12-17)
Glioblastomas are the deadliest type of brain cancer and are frequently associated with poor prognosis and a high degree of recurrence despite removal by surgical resection and treatment by chemo- and radio-therapy. Photodynamic therapy (PDT) is a treatment well known
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