475872
MnTMPyP
Cell-permeable superoxide dismutase (SOD) mimetic.
别名:
MnTMPyP, Mn（III）四（1-甲基-4-吡啶基）卟啉，四甲苯磺酸盐，氢氧化物
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关于此项目
经验公式（希尔记法）:
C72H65MnN8O13S4
分子量:
1433.53
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (TLC)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light
Quality Segment
assay
≥95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
black
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
细胞可渗透的超氧化物歧化酶（SOD）模拟物。即使在存在过量EDTA的情况下，也能催化O2– •的歧化（速率常数约为4 x 107 M-1 s-1）。可以替代缺乏这种酶的大肠埃希菌突变体中的SOD。MnTMPyP在体内充当NADPH/GSH：O2•氧化还原酶，而不是SOD模拟物。当氧化还原剂与生物抗氧化剂偶联时，也是一种有效的过氧亚硝酸盐还原酶。
Biochem/physiol Actions
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
Other Notes
Izbicka, E., et al. 1999.Cancer Res.59, 639.
Lee, J., et al. 1998.J. Am. Chem. Soc.120, 6053.
Gardner, P.R., et al. 1996.Arch.Biochem.Biophys.325, 20.
Liochev, S.I., and Fridovich, I. 1995.Arch.Biochem.Biophys.321, 271.
Faulkner, K.M., et al. 1994.J. Biol. Chem. 269, 23471.
Lee, J., et al. 1998.J. Am. Chem. Soc.120, 6053.
Gardner, P.R., et al. 1996.Arch.Biochem.Biophys.325, 20.
Liochev, S.I., and Fridovich, I. 1995.Arch.Biochem.Biophys.321, 271.
Faulkner, K.M., et al. 1994.J. Biol. Chem. 269, 23471.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable