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Merck
CN

475872

MnTMPyP

Cell-permeable superoxide dismutase (SOD) mimetic.

别名:

MnTMPyP, Mn(III)四(1-甲基-4-吡啶基)卟啉,四甲苯磺酸盐,氢氧化物

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关于此项目

经验公式(希尔记法):
C72H65MnN8O13S4
分子量:
1433.53
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (TLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated, protect from light
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assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated, protect from light

color

black

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

General description

细胞可渗透的超氧化物歧化酶(SOD)模拟物。即使在存在过量EDTA的情况下,也能催化O2– •的歧化(速率常数约为4 x 107 M-1 s-1)。可以替代缺乏这种酶的大肠埃希菌突变体中的SOD。MnTMPyP在体内充当NADPH/GSH:O2氧化还原酶,而不是SOD模拟物。当氧化还原剂与生物抗氧化剂偶联时,也是一种有效的过氧亚硝酸盐还原酶。

Biochem/physiol Actions

产物不与ATP竞争。
可逆:否
细胞可渗透性:具有

Other Notes

Izbicka, E., et al. 1999.Cancer Res.59, 639.
Lee, J., et al. 1998.J. Am. Chem. Soc.120, 6053.
Gardner, P.R., et al. 1996.Arch.Biochem.Biophys.325, 20.
Liochev, S.I., and Fridovich, I. 1995.Arch.Biochem.Biophys.321, 271.
Faulkner, K.M., et al. 1994.J. Biol. Chem. 269, 23471.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性:标准处理(A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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