475879
莫纳托
A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.
别名:
莫纳托, 4-（3-羟基苯基）-6-甲基-2-硫代-1，2，3，4-四氢-4H-嘧啶-5-羧酸乙酯，Eg5抑制剂I
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
S=C1N[C@H](C(=C(N1)C)C(=O)OCC)c2cc(ccc2)O
InChI
1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)/t12-/m0/s1
InChI key
LOBCDGHHHHGHFA-LBPRGKRZSA-N
相关类别
一般描述
一种有效的，可渗透细胞的，非微管蛋白相互作用的有丝分裂抑制剂。用单极纺锤体阻止哺乳动物细胞有丝分裂。在体外，它特异性抑制有丝分裂驱动蛋白Eg5的运动，Eg5是一种参与有丝分裂纺锤体组装和维持的马达蛋白（IC50=14µM）。
生化/生理作用
主要靶标
有丝分裂驱动蛋白Eg5
有丝分裂驱动蛋白Eg5
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：有丝分裂驱动蛋白Eg5为14µM
包装
用惰性气体包装
制备说明
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
其他说明
Kapoor，T.M.，et al. 2000.J. Cell Biol.150， 975.
Mayer，T.U.，et al. 1999.Science286, 971.
Mayer，T.U.，et al. 1999.Science286, 971.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Adélaïde Allais et al.
Development (Cambridge, England), 149(13) (2022-07-01)
Preimplantation embryos often consist of a combination of euploid and aneuploid cells, suggesting that safeguards preventing the generation and propagation of aneuploid cells in somatic cells might be deficient in embryos. In somatic cells, a mitotic timer mechanism has been
Gaudeline Rémillard-Labrosse et al.
Frontiers in cell and developmental biology, 12, 1337937-1337937 (2024-03-28)
Culture of oocytes and embryos in media under oil is a cornerstone of fertility treatment, and extensively employed in experimental investigation of early mammalian development. It has been noted anecdotally by some that certain small molecule inhibitors might lose activity
Aleksandar I Mihajlović et al.
EMBO reports, 24(11), e57227-e57227 (2023-10-05)
Chromosome segregation errors in mammalian oocyte meiosis lead to developmentally compromised aneuploid embryos and become more common with advancing maternal age. Known contributors include age-related chromosome cohesion loss and spindle assembly checkpoint (SAC) fallibility in meiosis-I. But how effective the
Stephen DiGiuseppe et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(22), 6289-6294 (2016-05-18)
During the entry process, the human papillomavirus (HPV) capsid is trafficked to the trans-Golgi network (TGN), whereupon it enters the nucleus during mitosis. We previously demonstrated that the minor capsid protein L2 assumes a transmembranous conformation in the TGN. Here
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