Name: 麦考酚酸-CAS 24280-93-1-Calbiochem
Brand: MM

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About This Item

经验公式（希尔记法）:

C₁₇H₂₀O₆

CAS Number:

24280-93-1

分子量:

320.34

MDL编号:

MFCD00036814

UNSPSC代码:

12352106

NACRES:

NA.77

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Product Name

麦考酚酸-CAS 24280-93-1-Calbiochem, An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP.

质量水平

100

描述

Merck USA index - 14 6327

方案

≥95% (HPLC)

表单

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze

颜色

white to off-white

溶解性

0.1 M NaOH: 10 mg/mL
ethanol: soluble

运输

ambient

储存温度

10-30°C

SMILES字符串

O1Cc2c(c(c(c(c2C)OC)C\C=C(\CCC(=O)O)/C)O)C1=O

InChI

1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+

InChI key

HPNSFSBZBAHARI-RUDMXATFSA-N

一般描述

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of IMP dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.

生化/生理作用

Cell permeable: no

Primary Target
Inosine monophosphate dehydrogenase

Product does not compete with ATP.

Reversible: no

制备说明

Following reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Langman, L.J., et al. 1995. Clin. Chem. 41, 295.
Senda, M., et al. 1995. Transplantation60, 1143.
Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res.204, 241.
Falkner, F.G., and Moss, B. 1988. J. Virol.62, 1849.
Cohen, M.B., et al. 1981. J. Biol. Chem.256, 8713.
Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA78, 2072.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

象形图

GHS08,GHS07,GHS09

警示用语：

Danger

危险声明

H302,H341,H360D,H372,H410

预防措施声明

P201 - P202 - P260 - P273 - P301 + P312 - P308 + P313

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral

靶器官

Immune system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)