475984
MyoVin-1
A pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V.
别名:
MyoVin-1
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关于此项目
经验公式（希尔记法）:
C29H26N6O3S
化学文摘社编号:
分子量:
538.62
UNSPSC Code:
12352200
NACRES:
NA.51
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale yellow
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
O=C(C1=CC=CC(SCC2=CC=CC(NC3=NC(NN=C4C5=CC=C(N6CCOCC6)C=C5)=C4C=N3)=C2)=C1)O
InChI key
JTMFLTNSCRPRHU-UHFFFAOYSA-N
General description
一种吡唑并嘧啶化合物，可阻止ADP从肌动球蛋白复合物中释放，并作为肌球蛋白V的肌动蛋白刺激的ATP酶活性的有效，可逆和非竞争性抑制剂（单头和双头肌球蛋白V的Ki=6.3和5.5 µM）。显示出优于肌球蛋白II和肌球蛋白IV的选择性（在50 µM时抑制<10%），并且仅最小程度地抑制Cdk1/B、CHK1、Plk1、Abl、ERK2、CKII和Aurora-B的激酶活性（在100 µM时抑制<10%）。
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Other Notes
Islam, K., et al. 2010.Angew.Chem. Int. Ed.49, 8484.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ana Rita Costa et al.
eLife, 9 (2020-03-21)
Neurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain- and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that controls axonal expansion
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 475984-5MG | 04055977184372 |