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Merck
CN
所有图片(1)

文件

480001

Millipore

NDSB-195

A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins.

别名:

NDSB-195, Dimethylethylammonium Propane Sulfonate

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About This Item

经验公式(希尔记法):
C7H17NO3S
分子量:
195.28
UNSPSC代码:
12611902
NACRES:
NA.21

质量水平

检测方案

≥95% (TLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

water: soluble

运输

ambient

储存温度

15-25°C

一般描述

A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. Zwitterionic over a wide pH range. Does not absorb significantly in the near-UV range. Easily removed by dialysis.

应用


  • Protein stabilizer, NDSB-195, enhances the dynamics of the β4 -α2 loop of ubiquitin.: This research explores how NDSB-195 stabilizes proteins by enhancing the dynamics of the β4-α2 loop of ubiquitin, providing insights into its mechanism of action as a protein stabilizer (Wang et al., 2016).

  • Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines.: The study demonstrates the effectiveness of NDSB-195 in suppressing the oligomerization of problematic compounds, showcasing its utility in biochemical and pharmaceutical applications (Mizukoshi et al., 2015).

  • Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor.: This article discusses the interaction of NDSB-195 with acidic fibroblast growth factor, emphasizing its role in preventing protein aggregation during biochemical processes (Xiang et al., 2008).

  • Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA-binding domain of the Ets transcription factor in complex with target DNA.: The study uses NDSB-195 in the preparation and crystallization process, enhancing the stability and quality of the DNA-binding domain crystals for X-ray diffraction analysis (Suwa et al., 2008).

警告

Toxicity: Irritant (B)

其他说明

Goldberg, M.E., et al. 1996. Folding & Design 1, 21.
Vuillard, L., et al. 1995. Anal. Biochem. 230, 290.
Vuillard, L., et al. 1995. Biochem. J. 305, 337.
Vuillard, L., et al. 1994. FEBS Lett.353, 294.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3


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