480748
Neuronal Differentiation Inducer, Isobavachin
A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM.
别名:
Neuronal Differentiation Inducer, Isobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one, Isobavachin, Isobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
drug control
Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
storage condition
OK to freeze, protect from light
color
pale yellow
solubility
DMSO: 100 mg/mL, clear, yellow
shipped in
ambient
storage temp.
−20°C
SMILES string
OC1=CC=C(C(CC(C2=CC=C(O)C=C2)O3)=O)C3=C1CC=C(C)C
General description
A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM. It is shown to elicit the down-regulation of p38 and JNK phosphorylation, and the up-regulation of ERK phosphorylation. Co-treatment with GGTI-298 (1000 nM), a Geranylgeranyltransferase I Inhibitor (Cat. No. 345883) selectively abolishes the IBA- but not Retinoic Acid-induced neuronal differentiation, which suggests that the differentiation inducing effect may involve protein prenylation.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Wang, D.Y., et al. 2011. Acta Pharmacol Sin32, 425.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable