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经验公式(希尔记法):
C21H26N7O17P3 · 4Na
化学文摘社编号:
分子量:
833.35
MDL number:
UNSPSC Code:
41106305
NACRES:
NA.51
Assay:
≥90% (HPLC), ≥93% (enzymatic)
Form:
solid
Solubility:
water: 50 mg/mL
Storage temp.:
−20°C
SMILES string
[P](=O)(O[P](=O)(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O[P](=O)(O)O)[n]4c5ncnc(c5nc4)N)O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C=C(CC=C2)C(=O)N)O
InChI
1S/C21H30N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChI key
ACFIXJIJDZMPPO-NNYOXOHSSA-N
description
Merck USA index - 14, 6348
assay
≥90% (HPLC), ≥93% (enzymatic)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
yellow
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
一种在利用脱氢酶和还原酶的许多反应中作为电子供体的普遍存在的辅酶。它是通过电子受体NADP+的还原而产生的。以下生物学途径涉及NADPH:光合作用过程中由CO2形成碳水化合物,维持红细胞中还原型谷胱甘肽的高水平,还原硫氧还蛋白。
Application
NADPH, tetrasodium salt, has been used:
- as a cofactor in the enzymatic synthesis of epoxidized metabolites from polyunsaturated fatty acids, facilitating the epoxidation reaction catalyzed by the cytochrome P450 enzyme BM3
- in microsomal assays to evaluate the metabolic stability of CHD1L inhibitors
- in conjunction with glutathione to reduce S-glutathionylated cysteine groups during the biotin switch assay, facilitating the detection of protein S-glutathionylation in the study of HLTF-deleted colorectal cancer models
Preparation Note
复溶后,等分并冷冻保存(-20°C)。贮备液在-20°C下可稳定保存至多2个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性:标准处理(A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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