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Merck
CN

481973

NADPH,四钠盐

A ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes.

别名:

NADPH,四钠盐, β-烟酰胺腺嘌呤二核苷酸磷酸盐,还原,4Na

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关于此项目

经验公式(希尔记法):
C21H26N7O17P3 · 4Na
化学文摘社编号:
分子量:
833.35
MDL number:
UNSPSC Code:
41106305
NACRES:
NA.51
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产品名称

NADPH,四钠盐, A ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes.

SMILES string

[P](=O)(O[P](=O)(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O[P](=O)(O)O)[n]4c5ncnc(c5nc4)N)O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C=C(CC=C2)C(=O)N)O

InChI

1S/C21H30N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI key

ACFIXJIJDZMPPO-NNYOXOHSSA-N

description

Merck USA index - 14, 6348

assay

≥90% (HPLC)
≥93% (enzymatic)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

yellow

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

Disclaimer

毒性:标准处理(A)

General description

一种在利用脱氢酶和还原酶的许多反应中作为电子供体的普遍存在的辅酶。它是通过电子受体NADP+的还原而产生的。以下生物学途径涉及NADPH:光合作用过程中由CO2形成碳水化合物,维持红细胞中还原型谷胱甘肽的高水平,还原硫氧还蛋白。

Preparation Note

复溶后,等分并冷冻保存(-20°C)。贮备液在-20°C下可稳定保存至多2个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

NADPH, tetrasodium salt, has been used:
  • as a cofactor in the enzymatic synthesis of epoxidized metabolites from polyunsaturated fatty acids, facilitating the epoxidation reaction catalyzed by the cytochrome P450 enzyme BM3
  • in microsomal assays to evaluate the metabolic stability of CHD1L inhibitors
  • in conjunction with glutathione to reduce S-glutathionylated cysteine groups during the biotin switch assay, facilitating the detection of protein S-glutathionylation in the study of HLTF-deleted colorectal cancer models

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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