A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 and MDA-MB-453 (IC₅₀= 0.9, 2.2, and 4.0 µM, respectively), and affects two HER-2-negative breast cancer cell lines, MCF-7 and MDA-MB-231 only at much higher concentrations (IC₅₀ = 22.1 and 19.6 µM, respectively). The compound is not expected to be a COX-2 inhibitor and its cellular target(s) and mechanism(s) of growth inhibition is yet to be seen.

Following reconstitution, aliquot and freeze (-20°C).

Chen, B., et al. 2009. Biochem. Pharmacol.77, 1787.
Su, B., et al. 2008. J. Comb. Chem.10, 475.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)