483125-M
Nω-Nitro-ʟ-arginine methyl ester hydrochloride
≥98% (HPLC), eNOS reversible inhibitor, solid
别名:
NG-硝基-L-精氨酸甲基酯盐酸盐, Nω-NO₂-L-Arg-OMe, NG-NO₂-L-Arg-OMe, L-NAME, HCl
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关于此项目
经验公式（希尔记法）:
C7H15N5O4 · xHCl
化学文摘社编号:
分子量:
233.23 (free base basis)
UNSPSC Code:
12352209
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze
desiccated (hygroscopic)
protect from light
desiccated (hygroscopic)
protect from light
产品名称
NG-硝基-L-精氨酸甲基酯盐酸盐, Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM).
SMILES string
[Cl-].[N+H3][C@@H](CCCN\C(=N\[N+](=O)[O-])\N)C(=O)OC
InChI
1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChI key
QBNXAGZYLSRPJK-JEDNCBNOSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white to off-white
solubility
water: 50 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
主要靶标
eNOS
eNOS
靶标IC50：500 nM可抑制eNOS
Disclaimer
毒性：标准处理（A）
General description
可溶性更高的精氨酸类似物，同时是一种竞争性缓慢可逆的内皮一氧化氮合酶抑制剂（IC50 = 500 nM）。可引起对乙酰胆碱诱导的大鼠主动脉环松弛的长期抑制（IC50 = 400 nM）。
细胞可渗透。可溶性更高的精氨酸类似物，同时是一种竞争性缓慢可逆的eNOS抑制剂（IC50 = 500 nM）。可引起对乙酰胆碱诱导的大鼠主动脉环松弛的长期抑制（IC50 = 400 nM）。
Other Notes
Baylis, C., et al. 1995.J. Pharmacol.Exp.Ther.274, 1135.
Dawson, V.L., et al. 1991.Proc.Natl.Acad.Sci. USA88, 6368.
Kubes, P., et al. 1991.Proc.Natl.Acad.Sci. USA 88, 4651.
Moncada, S., et al. 1991.Pharmacol.Rev. 43, 109.
Moore, P.K., et al. 1990.Br. J. Pharmacol.99, 408.
Dawson, V.L., et al. 1991.Proc.Natl.Acad.Sci. USA88, 6368.
Kubes, P., et al. 1991.Proc.Natl.Acad.Sci. USA 88, 4651.
Moncada, S., et al. 1991.Pharmacol.Rev. 43, 109.
Moore, P.K., et al. 1990.Br. J. Pharmacol.99, 408.
Preparation Note
溶解后，等分并冷冻保存（-20°C）。储备液可在-20°C最长稳定4个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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