484100
5-Nitro-2-(3-phenylpropylamino)benzoic Acid
Potent Cl⁻ channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method.
别名:
5-Nitro-2-(3-phenylpropylamino)benzoic Acid, NPPB, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II, ANO Blocker II, Anoctamin Blocker II
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关于此项目
经验公式（希尔记法）:
C16H16N2O4
化学文摘社编号:
分子量:
300.31
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
SMILES string
[N+](=O)([O-])c1cc(c(cc1)NCCCc2ccccc2)C(=O)O
InChI
1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)
InChI key
WBSMIPAMAXNXFS-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
yellow
solubility
DMSO: 5 mg/mL, warm ethanol: soluble
shipped in
ambient
storage temp.
10-30°C
Quality Level
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General description
Potent Cl– channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC50 = 8 µM).
Potent Cl- channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC50 = 8 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Cl⁻ channel blocker
Cl⁻ channel blocker
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM-100 µM as Cl-channel blocker
Other Notes
Illek, B., et al. 1992. Am. J. Physiol.263, C644.
Kirk, K., et al. 1992. J. Biol. Chem.267, 23475.
Breuer, W., et al. 1989. Biochem. Biophys. Res. Commun.163, 398.
Wangermann, P., et al. 1986. Pflugers Arch.407, S128.
Kirk, K., et al. 1992. J. Biol. Chem.267, 23475.
Breuer, W., et al. 1989. Biochem. Biophys. Res. Commun.163, 398.
Wangermann, P., et al. 1986. Pflugers Arch.407, S128.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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