489477
LSD1抑制剂II，S2101
The LSD1 Inhibitor II, S2101 controls the biological activity of LSD1. This small molecule/inhibitor is primarily used for Cell Signaling applications.
别名:
LSD1抑制剂II，S2101, S2101，LSD抑制剂II，BHC110抑制剂II，组蛋白赖氨酸脱甲基酶抑制剂IV，KDM1抑制剂II，MOA抑制剂II
产品名称
LSD1抑制剂II，S2101, The LSD1 Inhibitor II, S2101 controls the biological activity of LSD1. This small molecule/inhibitor is primarily used for Cell Signaling applications.
color
white
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
DMSO: 100 mg/mL
water: 25 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
相关类别
Disclaimer
毒性：标准处理（A）
General description
一种可渗透细胞的2-PCPA衍生物，可引起针对LSD1（IC50 = 0.99 µ M，KI=0.61 µM，kinact/KI=4560 M-1S-1）的基于机理的抑制，并且显示对MAO-B（KI = 17 µ M，kinact/KI=18 M-1S-1）和MAO-A（KI = 110 µM，kinact/KI=60 M-1S-1）的抑制活性低得多，与2-PCPA（目录号616431）（对于LSD1，IC50 = 184 µM，KI = 100 µ M，kinact/KI=58 M-1S-1，对于MAO-B，KI = 26 µ M，kinact/KI=271 M-1S-1，对于MAO-A，KI = 5 µ M，
kinact/KI=1050 M-1S-1）相比，其效价和选择性更高。在基于细胞的测定中进一步证实了LSD1的抑制作用，用S2101处理HEK293T人细胞导致H3K4me2的水平呈剂量依赖性增加，并且与2-PCPA相比，抑制作用强约50倍。
kinact/KI=1050 M-1S-1）相比，其效价和选择性更高。在基于细胞的测定中进一步证实了LSD1的抑制作用，用S2101处理HEK293T人细胞导致H3K4me2的水平呈剂量依赖性增加，并且与2-PCPA相比，抑制作用强约50倍。
Other Notes
Mimasu, S., et al. 2010.Biochemistry49, 6494.
Preparation Note
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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