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492042

Nrf2 Activator III, TAT-14 Peptide

Name: Nrf2 Activator III, TAT-14 Peptide
Brand: MM

The Nrf2 Activator III, TAT-14 Peptide modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications.

别名:

Nrf2 Activator III, TAT-14 Peptide, H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

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关于此项目

经验公式（希尔记法）:

C₁₃₇H₂₃₀N₄₈O₃₉

化学文摘社编号:

1362661-34-4

分子量:

3173.59

MDL number:

MFCD34790536

NACRES:

NA.51

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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属性

Quality Level

100

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

说明

General description

A 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75 µM). Also shown to suppress LPS-induced TNF-α secretion in THP-1 monocytes (~ 37.5 µM).

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

Steel, R., et al. 2012. ACS Med Chem Lett.3, 407.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c