495455
寡霉素
≥90% (mixture of A, B, and C isomers, HPLC), powder, Antibiotic, Calbiochem
别名:
寡霉素
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关于此项目
经验公式（希尔记法）:
C45H74O11
化学文摘社编号:
分子量:
791.06
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
寡霉素, A mixture of A, B, and C isomers.
InChI
1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+
InChI key
MNULEGDCPYONBU-ZUSSGZTJSA-N
assay
≥90% (mixture of A, B, and C isomers, HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
主要靶标
膜结合线粒体ATP酶（F1）
膜结合线粒体ATP酶（F1）
产品不与ATP竞争。
可逆：否
细胞渗透性：否
Disclaimer
毒性：刺激性（B）
General description
A、B和C异构体的混合物。一种大环内酯类抗生素，可抑制膜结合线粒体ATP合成酶，从而阻止磷酸基转移。诱导人淋巴母细胞和其他哺乳动物细胞凋亡。
Other Notes
Wolvetang, E.J., et al. 1994.FEBS Lett.339, 40.
Amoroso, S., et al. 1993.J. Pharmacol.Exp.Ther.264, 515.
Brustovetsky, N.N., et al. 1993.FEBS Lett.315, 233.
Nagamune, H., et al. 1993.Biochim.Biophys.Acta1141, 231.
Amoroso, S., et al. 1993.J. Pharmacol.Exp.Ther.264, 515.
Brustovetsky, N.N., et al. 1993.FEBS Lett.315, 233.
Nagamune, H., et al. 1993.Biochim.Biophys.Acta1141, 231.
Preparation Note
在重悬后分装并冻存于冰箱（-20°C。储备溶液在-20°C下可稳定保存2个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
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