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499050

Osteocalcin, Bovine Bone

Name: Osteocalcin, Bovine Bone
Brand: MM

别名:

Osteocalcin, Bovine Bone, Bone-Gla-Protein, BGP

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关于此项目

经验公式（希尔记法）:

C₂₆₃H₃₇₂N₆₆O₈₂S₂

分子量:

5834.29

NACRES:

NA.42

UNSPSC Code:

12352202

Form:

liquid

Assay:

≥98% (SDS-PAGE)

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属性

assay

≥98% (SDS-PAGE)

Quality Level

100

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

pI

4.0 - 4.5

shipped in

wet ice

storage temp.

−20°C

说明

General description

Single chain vitamin K-dependent protein produced by osteoblasts. Osteocalcin purified from bovine bone. Binds to phospholipid vesicles in the presence of Ca²⁺ (K_d = 6 µM). Also binds hydroxylapatite. Possible role in bone mineralization, bone resorption, and bone formation. Note: Gla corresponds to γ-carboxyglutamic acid.

Physical form

In 75 mM NaCl, 10 mM sodium phosphate buffer, pH 7.4.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Carter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
Watson, K.E., et al. 1994. J. Clin. Invest.93, 2106.
Tracy, R.P., et al. 1990. J. Bone Min. Res.5, 451.
Gendreau, M.A., et al. 1989. J. Biol. Chem.264, 6972.

H-Tyr-Leu-Asp-His-Trp-Leu-Gly-Ala-Pro-Ala-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Lys-Arg-Gla-Val-Cys²³-Gla-Leu-Asn-Pro-Asp-Cys²⁹-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val-OH (disulfide bond: 23 → 29)

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c