499610
(5Z)-7-Oxozeaenol, 来源于弯孢菌属
(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC50 = 8 nM).
别名:
(5Z)-7-Oxozeaenol, 来源于弯孢菌属, TAK1 抑制剂
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关于此项目
经验公式（希尔记法）:
C19H22O7
化学文摘社编号:
分子量:
362.37
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mg/mL, ethanol: 5 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
O1C(CC=CC(=O)C(C(CC=Cc2c(c(cc(c2)OC)O)C1=O)O)O)C
InChI
1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3
InChI key
NEQZWEXWOFPKOT-UHFFFAOYSA-N
General description
一种天然分离的可渗透细胞的真菌间苯二酚内酯，以ATP竞争性和不可逆的方式作为针对MAPKKK TAK1活性（IC50 =8 nM）的选择性和高效抑制剂，同时仅在更高的浓度下抑制MEK1（IC50=411 nM）和其他三种MAPKKK（MEKK1，ASK1和MEKK4的IC50 ≥268 nM）。显示抑制293细胞中IL-1诱导的/TAK1介导的JNK和p38磷酸化，但不抑制H2O2诱导的/TAK1非依赖性JNK和p38磷酸化。（5Z）-玉米醇，弯孢属（目录号499609）可以用作阴性对照。
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多6个月。
Other Notes
Windheim, M., et al. 2007.Biochem.J.404, 179.
Choo, M.K., et al. 2006.Mol.Cancer Ther.5, 2970.
Safwat, N., et al. 2005.Endocrinology146, 4814.
Ninomiya-Tsuji, J., et al. 2003.J. Biol. Chem.278, 18485.
Rawlins, P., et al. 1999.Int. J. Immunopharmacol.21, 799.
Choo, M.K., et al. 2006.Mol.Cancer Ther.5, 2970.
Safwat, N., et al. 2005.Endocrinology146, 4814.
Ninomiya-Tsuji, J., et al. 2003.J. Biol. Chem.278, 18485.
Rawlins, P., et al. 1999.Int. J. Immunopharmacol.21, 799.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable