跳转至内容
Merck
CN

499610

(5Z)-7-Oxozeaenol, 来源于弯孢菌属

(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC50 = 8 nM).

别名:

(5Z)-7-Oxozeaenol, 来源于弯孢菌属, TAK1 抑制剂

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C19H22O7
化学文摘社编号:
66018-38-0
分子量:
362.37
MDL number:
MFCD12912700
UNSPSC Code:
12352200
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

assay

≥95% (HPLC)

SMILES string

O1C(CC=CC(=O)C(C(CC=Cc2c(c(cc(c2)OC)O)C1=O)O)O)C

InChI

1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3

InChI key

NEQZWEXWOFPKOT-UHFFFAOYSA-N

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

相关类别

General description

一种天然分离的可渗透细胞的真菌间苯二酚内酯，以ATP竞争性和不可逆的方式作为针对MAPKKK TAK1活性（IC50 =8 nM）的选择性和高效抑制剂，同时仅在更高的浓度下抑制MEK1（IC50=411 nM）和其他三种MAPKKK（MEKK1，ASK1和MEKK4的IC50 ≥268 nM）。显示抑制293细胞中IL-1诱导的/TAK1介导的JNK和p38磷酸化，但不抑制H2O2诱导的/TAK1非依赖性JNK和p38磷酸化。（5Z）-玉米醇，弯孢属（目录号499609）可以用作阴性对照。

Preparation Note

复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多6个月。

Other Notes

Windheim, M., et al. 2007.Biochem.J.404, 179.
Choo, M.K., et al. 2006.Mol.Cancer Ther.5, 2970.
Safwat, N., et al. 2005.Endocrinology146, 4814.
Ninomiya-Tsuji, J., et al. 2003.J. Biol. Chem.278, 18485.
Rawlins, P., et al. 1999.Int. J. Immunopharmacol.21, 799.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Christoph Lammel et al.
Biomolecules, 10(9) (2020-08-23)
Twenty natural remedies traditionally used against different inflammatory diseases were probed for their potential to suppress the expression of the inflammatory markers E-selectin and VCAM-1 in a model system of IL-1 stimulated human umbilical vein endothelial cells (HUVEC). One third

相关内容

Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

"Toll-like Receptors (TLRs) are transmembrane proteins that are expressed on various immune cells. The extracellular N-terminal region of TLRs recognizes specific pathogen components. At least 13 different members of TLR family have been identified that detect different pathogen associated molecular patterns (PAMPs), including lipopolysaccharides, flagellin, bacterial CpG DNA, and viral RNA and DNA. Recognition of PAMPs by TLRs is considered as a key process for the induction of an inflammatory response."

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持