5.00469
S107
≥98% (HPLC), solid, RyR-Calstabin interaction stabilizer, Calbiochem®
别名:
RyR-Calstabin Interaction Stabilizer, S107, 7-methoxy-4-methyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine, Ryanodine Receptor Stabilizer, Rycal S107
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关于此项目
经验公式（希尔记法）:
C11H15NOS
化学文摘社编号:
分子量:
209.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
RyR-Calstabin Interaction Stabilizer, S107,
SMILES string
S1CCN(Cc2c1ccc(c2)OC)C
InChI key
BGVCEGVSQDOGSB-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 100 mg/mL
Quality Level
General description
RyR-Calstabin Interaction Stabilizer, S107 can protect hippocampal neurons from GABAergic synaptic changes caused by Abeta42 oligomers.
Application
RyR-Calstabin Interaction Stabilizer, S107 has been used in culture media for hypoxic exposures to study the impact of hypoxia on sarcoplasmic reticulum calcium leakage and expression of ryanodine receptor2 (RyR2).
Biochem/physiol Actions
Primary Target
RyR2
RyR2
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Hypoxia-Induced Sarcoplasmic Reticulum Ca2+ Leak Is Reversed by Ryanodine Receptor Stabilizer JTV-519 in HL-1 Cardiomyocytes
Trinh MD, et al.
Anatolian journal of cardiology, 26(6), 476-476 (2022)
The ryanodine receptor-calstabin interaction stabilizer S107 protects hippocampal neurons from GABAergic synaptic alterations induced by Abeta42 oligomers
Hidisoglu E, et al.
The Journal of Physiology, 600(24), 5295-5309 (2022)
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