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5.00498

HIF Inhibitor V

Name: HIF Inhibitor V
Brand: MM

别名:

HIF Inhibitor V, Hypoxia-Inducible Factor Inhibitor V, ( E)-3-(3-(4-Adamantan-1-ylphenoxy)acrylamido)benzoic acid morpholinoethyl ester

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关于此项目

经验公式（希尔记法）:

C₃₂H₃₈N₂O₅

化学文摘社编号:

1373443-16-3

分子量:

530.65

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥99% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

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属性

assay

≥99% (HPLC)

Quality Segment

100

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

说明

General description

A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1α accumulation in a manner similar to LW6 by upregulating Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC₅₀ = 120 nM vs 2.44 µM, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress HIF-1 target genes expression in HCT116 cultures and inhibit HUVEC tubule formation (effective conc. ≥2 µM) under hypoxia conditions.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Cell permeable: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Use only fresh DMSO for reconstitution.

Other Notes

Naik, R., et al. 2012. J. Med. Chem.55, 10564.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c