5.00554
MHY1485
≥97% (HPLC), solid, mTOR activator, Calbiochem®
别名:
mTOR活化剂，MHY1485
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关于此项目
经验公式（希尔记法）:
C17H21N7O4
化学文摘社编号:
分子量:
387.39
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
产品名称
mTOR活化剂，MHY1485,
InChI key
VHYUALWDIXAVIZ-UHFFFAOYSA-N
SMILES string
C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O
assay
≥97% (HPLC)
form
solid
potency
~2 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
pale yellow
solubility
DMSO: 12.5 mg/mL
storage temp.
2-8°C
Quality Level
Application
mTOR 激活剂 MHY1485 已用于活化帕金森病 (PD)小鼠的哺乳动物雷帕霉素靶蛋白 (mTOR) 通路，以逆转肿瘤坏死因子α诱导蛋白 3 (TNFAIP3) 对1-甲基-4-苯基吡啶 (MPP+) 诱导的小鼠及SK-N-SH 细胞的损伤。
Biochem/physiol Actions
可逆性：是
细胞可渗透性：具有
Disclaimer
毒性：标准处理（A）
General description
MHY1485 是一种哺乳动物雷帕霉素靶蛋白 (mTOR) 的小分子活化剂，通过阻止自噬体和溶酶体的融合，对自噬过程产生抑制作用，导致 LC3II 蛋白积累和自噬体增大。它还可通过抑制地塞米松引起的线粒体死亡途径，保护成骨细胞免受地塞米松引起的损伤。
Other Notes
Choi, Y. J., et al. 2012.PLoS.One.7, e43418.
Packaging
用惰性气体包装
Preparation Note
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yeon Ja Choi et al.
PloS one, 7(8), e43418-e43418 (2012-08-29)
Autophagy is a major degradative process responsible for the disposal of cytoplasmic proteins and dysfunctional organelles via the lysosomal pathway. During the autophagic process, cells form double-membraned vesicles called autophagosomes that sequester disposable materials in the cytoplasm and finally fuse
Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
Choi YJ, et al.
Testing (2012)
Tumor necrosis factor alpha-induced protein 3 mediates inflammation and neuronal autophagy in Parkinson?s disease via the NFkappaB and mTOR pathways
Chi M, et al.
Neuroscience Letters, 805, 137223-137223 (2023)
MHY1485 activates mTOR and protects osteoblasts from dexamethasone
Zhao S, et al.
Biochemical and biophysical research communications, 481(3-4), 212-218 (2016)
Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
Choi YJ, et al.
PLoS ONE (2012)
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