5.04841
5,7-Dichlorokynurenic Acid, Sodium Salt
别名:
5,7-Dichlorokynurenic Acid, Sodium Salt, 5,7-Dichloro-4-hydroxyquinoline-2-c-arboxylic acid sodium salt, DCKA
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关于此项目
经验公式（希尔记法）:
C10H4Cl2NNaO3
化学文摘社编号:
分子量:
280.04
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Segment
form
solid
potency
79 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 10 mM, 1 M NaOH: 100 mM
storage temp.
2-8°C
SMILES string
[Na+].Clc1c2c(nc(cc2O)C(=O)[O-])cc(c1)Cl
InChI
1S/C10H5Cl2NO3.Na/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14;/h1-3H,(H,13,14)(H,15,16);/q;+1/p-1
InChI key
VPRPMJHKWHCUFW-UHFFFAOYSA-M
General description
A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (Ki = 79 nM vs. [3H]-glycine).
Biochem/physiol Actions
Primary Target
NMDA receptors
NMDA receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Baron, B., et al. 1991. Eur. J. Pharmacol.206, 149.
Baron, B., et al. 1990. Mol. Pharmacol.38, 554.
Mugnaini, M., et al. 1998. J. Recept. Signal Transduct. Res.18, 91.
Baron, B., et al. 1990. Mol. Pharmacol.38, 554.
Mugnaini, M., et al. 1998. J. Recept. Signal Transduct. Res.18, 91.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable