5.04842
CGP 37849
别名:
CGP 37849, (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid
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关于此项目
经验公式（希尔记法）:
C6H12NO5P
化学文摘社编号:
分子量:
209.14
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[P](=O)(O)(O)C\C(=C\C(N)C(=O)O)\C
InChI
1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+
InChI key
BDYHNCZIGYIOGJ-DUXPYHPUSA-N
assay
≥99% (HPLC)
form
solid
potency
35 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
H2O: 100 mM
Quality Level
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General description
A highly potent competitive antagonist selective for NMDA receptors (Ki = 35 nM). Biologically viable admitted orally or systematically. Widely used in studies of epilepsy, schizophrenia, depression, stress and anxiety related mental disorders.
Biochem/physiol Actions
Primary Target
NMDA receptors
NMDA receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Slight warming is required for complete solubilization.
Other Notes
Serafini, G., et al. 2013. Curr. Pharmaceut. Design19, 1898.
Szewczyk, B., et al. 2012. Expert. Op. Invest. Drugs21, 91.
Przegalinski, E., et al. 2000. Neuropharmacol.39, 1858.
Maj, J., et al. 1993. Polish J. Pharmacol.45, 455.
Fagg, E., et al. 1990. Br. J. Pharmacol.99, 791.
Schmutz, M., et al. 1990. Naunyn-Schmiedebergʹs Arch. Pharmacol.342, 61.
Szewczyk, B., et al. 2012. Expert. Op. Invest. Drugs21, 91.
Przegalinski, E., et al. 2000. Neuropharmacol.39, 1858.
Maj, J., et al. 1993. Polish J. Pharmacol.45, 455.
Fagg, E., et al. 1990. Br. J. Pharmacol.99, 791.
Schmutz, M., et al. 1990. Naunyn-Schmiedebergʹs Arch. Pharmacol.342, 61.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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