5.05207
Mecamylamine Hydrochloride
别名:
Mecamylamine Hydrochloride, N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride
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关于此项目
经验公式（希尔记法）:
C11H21N · xHCl
化学文摘社编号:
分子量:
167.29 (free base basis)
UNSPSC Code:
12352116
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥98% (TLC)
Quality Segment
form
solid
potency
640 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
H2O: 100 mM
storage temp.
2-8°C
SMILES string
[Cl-].N(C1(C2CC(C1(C)C)CC2)C)C.[H+]
InChI
1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
InChI key
PKVZBNCYEICAQP-UHFFFAOYSA-N
General description
A potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette′s syndrome, Schizophrenia and various cognitive and mood disorders).
Biochem/physiol Actions
Primary Target
nAChR
nAChR
Reversible: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Harris, C., et al. 2013. Psychopharmacol.225, 291.
Lima, H., et al. 2013. Learning & Memory20, 120.
Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol.22, 198.
Bacher, I., et al. 2009. Expert Opin. Pharmacother.10, 2709.
Lippiello, M., et al. 2008. CNS Neurosci. Ther.14, 266.br>J. M. Young et al. 2001. Clin. Ther.23, 532.
Lima, H., et al. 2013. Learning & Memory20, 120.
Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol.22, 198.
Bacher, I., et al. 2009. Expert Opin. Pharmacother.10, 2709.
Lippiello, M., et al. 2008. CNS Neurosci. Ther.14, 266.br>J. M. Young et al. 2001. Clin. Ther.23, 532.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
警示词
Danger
危险代码
Hazard Classifications
Acute Tox. 3 Oral
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects