5.05275
ICI 118551 Hydrochloride
≥98% (HPLC), selective β2 adrenergic inverse agonist, solid
别名:
ICI 118551 Hydrochloride, (±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride
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关于此项目
经验公式（希尔记法）:
C17H27NO2 · xHCl
化学文摘社编号:
分子量:
277.40 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
ICI 118551 Hydrochloride,
SMILES string
N([C@H]([C@@H](O)COc1c2c(c(cc1)C)CCC2)C)C(C)C
InChI
1S/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3/t13-,16-/m0/s1
InChI key
VFIDUCMKNJIJTO-BBRMVZONSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mg/mL
storage temp.
10-30°C
Quality Level
General description
ICI-118,551 reduces hemangioblastoma viability by promoting cell apoptosis and inhibits the formation of hemangiospheres from VHL tumor cells. This antiangiogenic agent inhibits HIF-target genes. It also blocks constitutively activated HIF signaling in hemangioblastomas associated with von Hippel-Lindau disease. ICI-118,551 is a potent inhibitor of isoprenaline-stimulated adenylate cyclase activity in rabbit ciliary process cell preparations.
Biochem/physiol Actions
Primary Target
→2 adrenergic receptors
→2 adrenergic receptors
Reversible: yes
Target Ki: 1.2, 120 and 257 nM for →2, →1 and →3 receptors respectively.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bilski, A., et al. 1983. J. Cardiovasc. Pharmacol.5, 430.
Cook, S. et al. 1993. Br. J .Pharmacol.109, 1140.
Ten Berge, R., et al. 1995. Eur. J. Pharmacol.275, 199.
Strosberg, A., et al. 1996. TiPS17, 373.
Cook, S. et al. 1993. Br. J .Pharmacol.109, 1140.
Ten Berge, R., et al. 1995. Eur. J. Pharmacol.275, 199.
Strosberg, A., et al. 1996. TiPS17, 373.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The beta2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease
Cuesta AM, et al.
Scientific Reports, 9(1), 10062-10062 (2019)
The beta2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease
Cuesta AM, et al.
Scientific reports, 9(1), 10062-10062 (2019)
ICI 118,551: an effective ocular hypotensive agent with selectivity for the ciliary process beta 2-adrenoceptor and with minimal cardiac side effects.
Nathanson JA
British Journal of Pharmacology, 83(3), 821-821 (1984)
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