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About This Item
经验公式（希尔记法）:
C28H29N5OS
CAS Number:
分子量:
483.63
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥97% (HPLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
储存温度
−70°C
SMILES字符串
[s]1c2c(cc1c3nc(ncc3)Nc4ccc(cc4)C(=O)N5CCC(CC5)N6CCCC6)cccc2
InChI
1S/C28H29N5OS/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31)
InChI key
BWZJBXAPRCVCKQ-UHFFFAOYSA-N
一般描述
A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.
生化/生理作用
Cell permeable: yes
Primary Target
IKK-2, IKK complex, and IKK-1
IKK-2, IKK complex, and IKK-1
Reversible: yes
包装
Packaged under inert gas
外形
A 10 mM (500 µg/103 µL) sterile-filtered solution of IKK Inhibitor VII (Cat. No. 401486) in DMSO.
制备说明
Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
其他说明
Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett.16, 108.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
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