5.05483
FFN511
别名:
FFN511, Fluorescent False Neurotransmitter 511, Vesicle Monoamine Transporter (VMAT2) Substrate, FFN511
InChI key
SKTIZSRPCXRDHX-UHFFFAOYSA-N
InChI
1S/C17H20N2O2/c18-6-5-11-10-15(20)21-17-13-4-2-8-19-7-1-3-12(16(13)19)9-14(11)17/h9-10H,1-8,18H2
assay
≥99% (HPLC)
form
solid
potency
1 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 5 mM
storage temp.
−20°C
Quality Level
General description
A fluorescent false neurotransmitter that acts as an optical tracer that inhibits serotonin binding to VMAT2-containing membranes (IC50 = 1 µM). Compound has been used to assess the functional status of TH positive neurons by fluorescent measurement of uptatke and release.
Biochem/physiol Actions
Primary Target
VMAT2
VMAT2
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Dulcis, D. et al. 2013. Science340, 449.
Gubernator, N. G. et al. 2009. Science324, 1441.
Gubernator, N. G. et al. 2009. Science324, 1441.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Niko G Gubernator et al.
Science (New York, N.Y.), 324(5933), 1441-1444 (2009-05-09)
The nervous system transmits signals between neurons via neurotransmitter release during synaptic vesicle fusion. In order to observe neurotransmitter uptake and release from individual presynaptic terminals directly, we designed fluorescent false neurotransmitters as substrates for the synaptic vesicle monoamine transporter.
Davide Dulcis et al.
Science (New York, N.Y.), 340(6131), 449-453 (2013-04-27)
Neurotransmitters have been thought to be fixed throughout life, but whether sensory stimuli alter behaviorally relevant transmitter expression in the mature brain is unknown. We found that populations of interneurons in the adult rat hypothalamus switched between dopamine and somatostatin
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