5.05483
FFN511
别名:
FFN511, Fluorescent False Neurotransmitter 511, Vesicle Monoamine Transporter (VMAT2) Substrate, FFN511
方案
≥99% (HPLC)
质量水平
表单
solid
效能
1 μM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 5 mM
储存温度
−20°C
InChI
1S/C17H20N2O2/c18-6-5-11-10-15(20)21-17-13-4-2-8-19-7-1-3-12(16(13)19)9-14(11)17/h9-10H,1-8,18H2
InChI key
SKTIZSRPCXRDHX-UHFFFAOYSA-N
一般描述
A fluorescent false neurotransmitter that acts as an optical tracer that inhibits serotonin binding to VMAT2-containing membranes (IC50 = 1 µM). Compound has been used to assess the functional status of TH positive neurons by fluorescent measurement of uptatke and release.
生化/生理作用
Primary Target
VMAT2
VMAT2
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Dulcis, D. et al. 2013. Science340, 449.
Gubernator, N. G. et al. 2009. Science324, 1441.
Gubernator, N. G. et al. 2009. Science324, 1441.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Niko G Gubernator et al.
Science (New York, N.Y.), 324(5933), 1441-1444 (2009-05-09)
The nervous system transmits signals between neurons via neurotransmitter release during synaptic vesicle fusion. In order to observe neurotransmitter uptake and release from individual presynaptic terminals directly, we designed fluorescent false neurotransmitters as substrates for the synaptic vesicle monoamine transporter.
Davide Dulcis et al.
Science (New York, N.Y.), 340(6131), 449-453 (2013-04-27)
Neurotransmitters have been thought to be fixed throughout life, but whether sensory stimuli alter behaviorally relevant transmitter expression in the mature brain is unknown. We found that populations of interneurons in the adult rat hypothalamus switched between dopamine and somatostatin
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