5.05484
SB-277011-A Dihydrochloride
别名:
SB-277011-A Dihydrochloride, SB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A
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关于此项目
经验公式（希尔记法）:
C28H30N4O · 2HCl
化学文摘社编号:
分子量:
511.49
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
方案
≥98% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
white
溶解性
water: 100 mM
储存温度
2-8°C
SMILES字符串
Cl.Cl.N4(CCc5c(ccc(c5)C#N)C4)CC[C@@H]1CC[C@H](CC1)NC(=O)c2c3c(ncc2)cccc3
InChI
1S/C28H30N4O.2ClH/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27;;/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33);2*1H/t20-,24-;;
InChI key
HEZIOTGUXSPDAK-ONAIBGCWSA-N
一般描述
A brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.
生化/生理作用
Primary Target
D3
D3
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Collins, G. T. et al. 2005. J. Pharmacol. Exp. Ther.314, 310.
Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther.294, 1154.
Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther.294, 1154.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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