5.05762
(+/-)-Clopidogrel Hydrogensulfate
别名:
(+/-)-Clopidogrel Hydrogensulfate, Purinergic P2Y12 Receptor Antagonist, (+/-)-Clopidogrel, Plavix
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经验公式（希尔记法）:
C16H16ClNO2S · xH2SO4
化学文摘社编号:
分子量:
321.82 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[S](=O)(=O)([O-])O.[s]1c2c(cc1)C[N+H](CC2)C(c3c(cccc3)Cl)C(=O)OC
InChI
1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)
InChI key
FDEODCTUSIWGLK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 25 mg/mL
storage temp.
2-8°C
Quality Level
Disclaimer
Toxicity: Standard Handling (A)
Biochem/physiol Actions
Primary Target
P2Y₁₂
P2Y₁₂
Reversible: no
General description
A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y12 receptors. Blocks ADP-induced platelet aggregation and serves as an anti-thrombotic agent. Shown to reduce vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. Clopidogrel is a prodrug that requires activation by CYP enzyme system to produce its pharmacologically active metabolite.
Other Notes
Liu, O., et al. 2012. PLoS One.7, e51707.
Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.
Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
wgk
WGK 3
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible, corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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