5.05881
(R)-(+)-SKF38393 Hydrochloride
别名:
(R)-(+)-SKF38393 Hydrochloride, Dopamine D1/D5 Receptor Partial Agonist, (R)-SKF-38393 Hydrochloride, SKF-38393, SKF38393, SKF 38393
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关于此项目
经验公式（希尔记法）:
C16H17NO2 · xHCl
化学文摘社编号:
分子量:
255.31 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
Cl.N1C[C@@H](c3c(cc(c(c3)O)O)CC1)c2ccccc2
InChI
1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1
InChI key
YEWHJCLOUYPAOH-PFEQFJNWSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 100 mM
storage temp.
−20°C
Quality Level
General description
A benzazepine derivative that acts as a selective Dopamine D1/D5 receptor partial agonist. Examination of the isomers in several in vitro and in vivo tests for both central and peripheral dopaminergic activity revealed that activity resided almost exclusively in the R isomer. The results suggest that the properly oriented 1-phenyl substituent of 1 is important for dopamine-like activity. Reported to have stimulant and anorectic effects.
Biochem/physiol Actions
Primary Target
D₁
D₁
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Trampus, M. et al. 1993. J. Pharmacol.235, 83.
Cooper, S. J. et al. 1990. Psychopharmacol.100, 182.
Dubois, A. et al. 1986. Neurosci.19, 125.
Kaiser, C. C. et al. 1982. J. Med. Chem.25, 697.
Cooper, S. J. et al. 1990. Psychopharmacol.100, 182.
Dubois, A. et al. 1986. Neurosci.19, 125.
Kaiser, C. C. et al. 1982. J. Med. Chem.25, 697.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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