5.05981
PK11195
别名:
PK11195, TSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195
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关于此项目
经验公式（希尔记法）:
C21H21ClN2O
化学文摘社编号:
分子量:
352.86
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
storage temp.
2-8°C
SMILES string
Clc1c(cccc1)c2nc(cc3c2cccc3)C(=O)N(C(CC)C)C
InChI
1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
InChI key
RAVIZVQZGXBOQO-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
potency
20 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM
Quality Level
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General description
An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20 nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (˜100 µM).
Biochem/physiol Actions
Primary Target
peripheral bezodiazepine receptor
peripheral bezodiazepine receptor
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Naoi, M., et al., 2013. J. Neural Transm.In press
Casellas, P., et al., 2002. Neurochem. Int.40, 475.
Waterfield, J.D., et al., 1999. Rheumtology38, 1068.
Casellas, P., et al., 2002. Neurochem. Int.40, 475.
Waterfield, J.D., et al., 1999. Rheumtology38, 1068.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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