5.06073
Glutaminase Inhibitor, Compound 968
InSolution, ≥99%, A cell-permeable benzophenanthridinone compound
别名:
InSolution Glutaminase Inhibitor, Compound 968, GAC Inhibitor, GLS1 Inhibitor I, KGA Inhibitor I, Kidney-Type Glutaminase Inhibitor I, 5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one
产品名称
Glutaminase Inhibitor, Compound 968, InSolution, ≥99%, A cell-permeable benzophenanthridinone compound
assay
≥99% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
storage temp.
−70°C
Quality Level
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Preparation Note
Following initial thaw slight warming may be required to resolubilize. Aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
mitochondrial glutaminase
mitochondrial glutaminase
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10 µM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cells). Shown to effectively shrink tumor size in P-493 B xenografted mouse model (200 µg per inj. i.p., 12 days).
Other Notes
Wang, J.B., et al. 2010. Cancer Cell18, 207.
Packaging
Packaged under inert gas
Physical form
A 10 mM (5 mg/1.05 ml) sterile-filtered solution of Glutaminase Inhibitor, Compound 968 (Cat. No. 352010) in DMSO.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - (refers to pure substance)
flash_point_c
87 °C - (refers to pure substance)
法规信息
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