5.06125
Paroxetine Hydrochloride
别名:
Paroxetine Hydrochloride, 5-HT transporter, Paroxetine, Paxil
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经验公式（希尔记法）:
C19H20FNO3 · xHCl
化学文摘社编号:
分子量:
329.37 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
storage temp.
2-8°C
SMILES string
Fc1ccc(cc1)[C@H]2[C@@H](CNCC2)COc3cc4c(cc3)OCO4
InChI
1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
InChI key
AHOUBRCZNHFOSL-YOEHRIQHSA-N
assay
≥99% (HPLC)
form
solid
potency
0.065 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: soluble
Quality Level
General description
A very potent uptake inhibitor highly selective for 5-HT transporter (Ki = 0.065 nM and 0.05 nM for human and rat 5-HT transporters, respectively). A popular antidepressant drug of the SSRI type. Used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms.
Biochem/physiol Actions
Primary Target
5-HT Uptake Transporter
5-HT Uptake Transporter
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Brittain, G., et al. 2012. Profiles of drug substances, excipients, and related methodology.38, 407.
Bourin, M., et al. 2001. CNS Drug Rev.7, 25.
Thomas, R., et al. 1997. Psychopharmacology (Berl).93, 193.
Bourin, M., et al. 2001. CNS Drug Rev.7, 25.
Thomas, R., et al. 1997. Psychopharmacology (Berl).93, 193.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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